Chapter 50: The ‘Death Gene’ and How to Re-set it, Alzheimer’s Disease and the ‘Placebo Connection’
http://darrylpenney.com
Abstract: Alzheimer’s Disease and Vascular Dementia are considered to be a result of a ‘modern’ lifestyle and readily preventable through state of mind, nutrition and exercise, which leads to componentization that shows that the body is not programmed for death in a hardware sense, but is in a software sense. The Cambrian saw a major change in reality as animals evolved sight and improved consciousness (sufficiency) but death was needed to enable evolution (necessity), the ‘placebo/nocebo connection’ of the cells required submission to the (resultant) mind and the weakening of the old animals with time, however, a change in our reality may be able to over-ride this and could see our lifetimes greatly extended for those that make the effort, and that determination invokes Survival of the Best that is the ultimate result of evolution. Changing our reality could also be an answer to age discrimination in the workforce.
‘Dementia is therefore now one of society’s most pressing social and medical issues. In a historical context, it is clear why this has come to pass. In the United States at the turn of the nineteenth century, infection was the main killer of adults, whose average life span was just 47 years. Alzheimer’s Disease and Vascular Dementia are mainly late-onset diseases, manifesting usually after the age of 60. Thus, at the start of the twentieth century, there were simply too few people in the right age range for dementia to be a major problem.’ (Maintain Your Brain, Dr Michael J Valenzuela, p 23) I might also mention that food was different then.
‘Economic modelling by Access Economics has found that if current rates of dementia were to translate to the bulging baby-boomer cohort, then annual spending on health as a proportion of gross domestic product would increase from 0.5 per cent to 3 per cent within a generation. In short, the increased occurrence of dementia within the next 30 years entails the risk of bankrupting our governments.’ (p 25)
Clearly, dementia is a threat to anyone that wants to live a long time and little is known about its cause. As time passes, more and more research accumulates and we get a better idea of how to prevent it. I came across a book, Maintain Your Brain by Dr Michael J Valenzuela that explains dementia in a context that makes sense and allows us to (hopefully) feel more secure that we can avoid it.
I want to add enough quotations to show the line of thought, but not so many as to confuse the reader, but it should be borne in mind that this is a simplification in a very complex and poorly understood subject. The saving grace, and the reason that I am attempting this is because it is so important and the solution is so simple and fits so well into a lifestyle that is necessary for anti ageing. It will be seen that the problem is not dementia, but a problem of strength of mind, which brings us back to Survival of the Best.
‘Alzheimer’s disease … is a slow process of gradual loss and shrinkage of brain cells that almost always starts in the same place in the brain, deep near the base of the skull … Vascular dementia … begins with a stroke – a sudden loss of blood supply to a part of the brain, causing damage and death of brain cells.
It follows that the best way to avoid Vascular Dementia is to avoid having a stroke in the first place, which requires us to do our best to avoid vascular disease in general. And we already know how to do this! Even the most sanguine person when it comes to their own health will recognise some of the five most important vascular risk factors: smoking, obesity, bad cholesterol, diabetes and high blood pressure.’ (p 52)
It is now a well established finding that individuals with a greater number of cardiac risk factors (smoking, hypertension, diabetes, hypercholesterolemia, and so on) are also at increased risk of developing Alzheimer’s Disease (and Vascular Dementia, of course).’ (p 54) ‘The studies have shown that more amyloid protein begins to be secreted into the space around the cells that are ischemic (reduced blood supply). This is quite an exciting finding, because for the first time there was a clue that the dynamics of blood supply may be involved in the formation of amyloid plaques, the main pathological feature of Alzheimer’s Disease…. So-called pure cases of Alzheimer’s Disease are actually not all that common in real life. More common is the existence of both diseases at the same time, so-called mixed dementia.’ (p 55)
‘Microbleeds and AD plaques coincide in ‘brain space’ far more often than could be expected by chance alone … Very often, in fact, a microbleed was noted at a branch point of a capillary with an AD plaque sitting directly on top of it … Adding to the argument is the observation that microbleeds first begin to develop in the hippocampus, an area first affected in AD dementia…. I suspect that the hippocampus has the most tangled and complex vascular supply of any part of the brain …. is particularly susceptible to microbleeds and therefore the development of Alzheimer plaques.’ (p 57)
‘So finally, after almost 100 years of research into dementia, we have an effective medical weapon in our armoury – good old blood pressure tablets!’ (p 62) ‘Lesson #1. There is a strong probability that keeping blood pressure in the healthy range reduces your risk of dementia…. A healthy heart means a healthy brain. Therefore all the same recommendations for avoiding cardiovascular disease apply to the brain as well.’ (p 67)
The above tells a simplified story, and we are looking for a simple story of how this all fits together so that we can deal with it easily. The trillions of cells that have been part of our body at various times are (effectively) identical and were derived from one sperm/egg with each cell differentiating (probably) by covering parts of the DNA similar to the way methylation works. So, if each cell is (effectively) identical we could agree that ‘a healthy heart means a healthy brain’, but this is a simplification that has gone too far, and whilst it’s the heart’s job to pump blood, the brain is the major reason that the heart pumps blood because the cells have a ‘connection’ to produce a mind to change their reality. This will be made clearer later, but for now, the brain needs mental exercise to remain healthy.
‘While much attention is given to how we can modify and change risk factors for dementia such as hypertension, smoking, education, and so forth, the simple ageing process dwarfs these by a factor of more than 7:1 (p 72) Given, from above, that dementia could bankrupt the government, how many resources could be saved if people lived and worked longer and had less time ‘in care’ over the latter end of their life? I have come across the question of whether we have a ‘built-in’ lifespan and it does seem that this is true and that the limit is about 120 years. However, this may appear to be the case under the present circumstances of our thinking/reality, and as strange as it seems, I present the following means of (possibly) greatly extending our lifetimes.
As has been mentioned before that the body is a collection of cells that have created a reality that is unavailable to the individual cell and also, each cell is a component and able to handle whatever it is necessary to handle within normal limits. If any part of the body could not handle what was necessary, the animal would be unsuccessful and be eliminated by Survival of the Fittest. The problems of organs breaking down shows that we have moved outside of the normal limits imposed by the reality of the body, and that reality is, in the main, the hunter/gatherer mode. The task is to match the reality that the body requires with the reality of modern life.
Thus, we could say that (some of the) breakdowns in the body that are occurring have been caused by changes in our food supply. ‘Most of us are eating ourselves to death: only 10 percent of Americans eat the foods that would enable them to be free of chronic disease and premature death.’ (Super Foods Rx, Steven Pratt and Kathy Matthews, p 12) The food supply that our body evolved to use ensured that our body was composed of healthy components that included each cell, our organs (of cells) up to our body (of cells) itself. This sentence requires some explanations. The ‘body’ is a group of cells that have differentiated into organs that do the same job as the components in each cell. From the Rule of Life, the simplest organization of an entity whether a cell or a body must follow a set organization, as we have seen previously.
A ‘component’ is a concept such as an alternator in a car. It is designed to stand-alone, produce a current sufficient for normal usage and last a reasonably long time. The cells, organs and the whole body have evolved to satisfy similar criteria because that is the simplest in an organizational sense (Rule of Life). The cell is a living organism, and so is the body, whilst organs are similar but form part of a body and don’t exist on their own and still fit the description of a component. However, there are distinct differences with the example of the alternator and ‘life’ components, not in organizational form, but in the mechanics, as would be expected.
They are the same because they all stand-alone, produce a product sufficient for normal usage and last a reasonably long time, so let’s look deeper. ‘Stand alone’: the components of a cell, the cell, the organs in the body and the body are all entities that ‘do a job’ just as the ‘bolt-on’ alternator does a job. ‘Produce a product’: is fairly obvious and in the case of the cell and body, it is to breed. However, more complex is the concept of ‘Componentization’, which is a ‘logic machine’ that was mentioned in the first Law of Life and is the ability for a component to increase an output in some way and an example is the atom and the ‘states’ of an atom produce light of different energies. Another example is Survival of the Fittest dovetailing with our success in breeding, in that the more successful that you are, the more progeny that you leave.
Componentization has to have limits of output that depends on the size and robustness of the component. For example, a 12 volt truck alternator would work in a car, if it physically fitted, but a car alternator would be too small (in output) for a truck. In life-systems, this ‘designer’s decision’ has to be handled differently because Survival of the Fittest demands that the minimum sized component be used (that will handle the job) and componentization demands that the component be adequate to ‘do the job’, plus some extra. The way that those two requirements evolved is the ‘use it or lose it’ principle, where the component, such as a muscle, is able to apply a range of forces, but can increase its range through necessity, which is produced by needing to use the muscle more, which is activated by exercise. Similarly, myelin sheath is laid down on nerves when the speed of the nerve needs to increase to decrease ‘reaction time’ in the face of persistent threats.
‘Last a reasonably long time’: is a trade-off of a number of attributes such as cost, amount of current output and length of life that a designer has to take into account. Living systems evolve, so, a ‘living’ component has to have a figure ‘set’ into it for how long it will last, and the answer is (practically) indefinitely because the component ‘renews’ itself regularly throughout its life. An exception to this statement is that brain cells, when adequately nourished, appear to last ‘forever’, as shown above, and that dementia results from a mismanagement brought about by modern living that causes a breakdown in one or more of the components (state of mind, nutrition and exercise). It is interesting that the necessity to retain the best and longest memories (heritable) requires that neurons don’t die (heritable) and as every cell in the body is identical, every cell (as a component) has an ‘infinite’ life which means that our body does not need to die!
This is a startling derivation! However, predation, accidents, infections and so forth will take their toll, but it appears that we are able to live ‘forever’, but then there are the internal problems of DNA ‘mistakes’, mutations etc. that also take their toll, so there is an upper limit to life. This upper limit would depend on the state of the three factors (state of mind, nutrition and exercise) throughout life. However, there is another reason why we should die, and that is logic/organization, but over the last 10,000 years we have changed the reality of the world to suit ourselves, so can we change our reality to extend our lives?
So, given that we are composed of components that don’t wear out and components that can produce more when required, we should be able to maintain our lifestyle/performance/abilities over the greater part of our life provided that we adhere to the second Law of Life (mental state, nutrition and exercise). In other words, the rectangularizing of the effectiveness versus age graph is our aim, so that our body performs well throughout life until the very end.
The question is ‘why do we die?’ We, and all the components of which we are made, do not have a time frame built in, but has evolution forced a time frame on us? If we continued to improve during life, the old animals know more and could survive better and superior old animals would be mating with old animals and clearly this could lead to problems if the theories of aging are correct and damage to DNA etc. occurs.
Old animals have the knowledge to find better nutrition and the experience to sight and flee predators, so how could evolution evolve a scheme to make old animals more likely to be caught in the light of these two factors. Clearly, there must be something that makes the old, a meal, and the young more nimble. I believe that the state of mind (out of state of mind, nutrition and exercise) is used along with the ‘use it or lose it’ principle (that is a part of componentization) and the Rule of Life to accomplish this turn-around.
We surmise that the old have the hardware to be superior to the young, but I have suggested a software solution to the problem. A software solution is necessary because there is only hardware and software solutions, and it can’t be hardware, as we have seen with nerve cells. So, this software solution has to be ‘strong’ enough to cause the old to die preferentially against the young in order that the animals survive as a group.
The present situation of old human females helping the younger fertile females shows how it is done, and it is the ‘best’ method, because that is the way that it is done (Rule of Life). This is the ‘grandmother effect’ that, in humans, has evolved to limit breeding to the younger females and could have evolved naturally because the number of birth defects rises sharply with age. From a family perspective, a family with less impaired children would be more successful than a family with more burdens to their survival, especially as human offspring require so much care, and this aligns with the ‘inbuilt’ necessity of tribe members moving to a new tribe to limit inbreeding. This termination of fertility would reduce the chance of passing on defects in DNA that occur with ageing of the mother, because there is no way to select the egg that is used. With males, the situation is different because the sperm is ‘selected’ by having to ‘race’ competitors and so, this could be the reason that males are always fertile.
Many references have been made that old people put on muscle easily when they exercise. On a personal note, I am over 70 years and I slowly built the number of ‘push-ups’ that I do each day to 100 (2×50) before breakfast. It was very much harder to get my balance (one leg, eyes closed) to 4 minutes (4×1 minute) probably because it required brain plasticity changes and nerve transmission speeds to increase, presumably by laying down more myelin. I should say that I have left formal exercise at that point only because I feel that it is sufficient with working, dancing etc. As mentioned previously, balance is one of the neglected senses and is crucial to prevent slowing down as we age. Good balance leads to confidence of movement, faster movement and that is state of mind and you ARE younger!
The Rule of Life says that the organization of this mechanism of making the old die before the young will be simple, and I believe that this is so, as in the following. One could say that gradual aging is natural as mutations etc. build-up, but accelerated ageing is not, because it is the mechanism that kills off the old and leaves the young. The method used is, I believe, componentization working in reverse and we call it sarcopenia, which is the loss of muscle caused by lack of exercise. We see its effect around us all the time: children run, adults walk and the elderly hobble. I said that it was simple, so simple that I had better point it out again, and emphasise that ‘use it, AND gain it’ is fundamental to Survival of the Fittest and the reason that we evolved. Actually, it is componentization where ‘use it’ leads to a higher level and more success at leaving offspring. The reverse is also the reason that we evolved and is ‘don’t use it AND lose it’ as a means of weakening the old to preserve the young. This continuum is contained within the concept of componentization.
We think that it is natural that old people slow down and retire and they look forward to slowing down because no one wants to work. But, if we look at the phrase ‘children run, adults walk and the elderly hobble’, we could say the young run, the middle aged walk and old hobble, but if we turn it around, is a person that runs, young, middle aged or old? This is ‘state of mind’ and it is one of a triumvirate of interlocking parts, together with nutrition and exercise and they have been discussed previously, and such is their importance, they form the second Law of Life.
At this point, it would be sensible to ask the question ‘is state of mind strong enough to bring about such a bizarre turn around to make the strongest into the weakest through sacopenia?’ I would say ‘yes’, because it happened, and it had to happen if we were to evolve, however, put another way, this process evolved, and it had to evolve because it has evolved and strength of mind plays no part, only success in producing superior offspring. In other words, ‘don’t use it and lose it’ is an iterative process, whereas strength of mind is a function of the mind and is not applicable in this case. It might make more sense to say that iteration is a Truth and the mind/brain uses iteration and takes it to a higher level.
So, let’s start from the beginning, that cells evolved into multicellular animals in order to take their cellular organization and evolve it into the organs of the animal and so making the animal large enough for a brain to evolve so as to attain a new reality which required a mind and lensed eyes. This has been discussed before, that every cell is linked together so as to form a brain and there is a two-way conversation between the cells and the mind that is produced. This communication is called the placebo/nocebo effect and it is so powerful that it can cure or kill an individual animal. This ability to kill is shown in humans as ‘pointing the bone’, and reflects the power handed to the new reality (the creation of a mind) by the cells that were bound by the restriction (in size) brought about by the thickness of the cell walls.
After this description, this might be the best place to define a ‘placebo/nocebo connection’ purely to put things into perspective and repeat a complicated process. Cells could only progress by joining together, differentiating to again set-up the organizational parts of the cell to form larger components (in a multicellular body), but a point was reached where a new reality came into being called the mind. Every cell contributed to the mind and every cell obeyed the mind, but componentization led to survival of the fittest and also to protecting the breeders, the youngest females have less age defects, at the expense of the older females. Notice that this contains the placebo/nocebo effect, but adds a lot more, and the organizational ‘strength’ of the placebo/nocebo ‘connection’ is reflected in the ‘strength’ of the herd formation that is almost universal.
If we want to turn off this software, that is an integral part of our evolution, to extend our lives, we must work within the second Law of Life and turn evolution on its head, another example of how powerful is the existing practice that we have to undo is to consider that old animals fall behind and are killed by predators, and that is the way that it has to be for Survival of the Fittest that has brought us to the Palaeolithic, 10,000 years ago. It is not altruism, it is not natural, but it is necessary organizationally for evolution to work because the best breeders MUST survive, preferentially, especially for humans that require years to bring up children. Now, if we succeed in making the old supreme, we need to create a new reality and that reality is Survival of the Best.
In fact, our reality has changed as we have over-run the planet in modern times by using the mind/brain on a part of the Mathematics of the Mind, and that is mathematics, and that led to technology. However, our body’s reality remains in the Palaeolithic and the problem is to reconcile the two, and to do that we need Survival of the Best, which has been discussed before. It is not surprising that people suitable to be included in the Best would have the qualities needed to extend life, namely determination, knowledge, be successful etc. and NOT have the negative qualities of drug and alcohol addiction, mental and personality problems etc. because they have to turn around their state of mind so that they do not slow down, must eat nutritiously and exercise. Also, their state of mind should be to move fast, work hard for a few hours a day and socialize to a reasonable extent. I should point out that the brain also requires exercise by learning (relatable) facts, and as we have seen, intelligence/creativity depends on this for continued growth.
Finally, it is said that old people do not absorb nutrients well, but if old people were rejuvenated, as above, would this still be the case? ‘Scientists don’t even fully understand exactly why our bodies need sleep, but they know that we do. Sleep generates hormones, such as human growth hormone, the ultimate anti-aging hormone (released only in the deep stages of sleep)’. (The Most Effective Ways to Live Longer, Jonny Bowden, p 78) ‘You can raise growth hormone levels (IGF-1 levels) on your own … its released during deep sleep, so anything that helps you sleep more deeply and restfully may have an effect … And very strenuous exercise will also raise it.’ (p 214)
The above paragraph shows that many biological factors are involved and my idea is to work with evolution and leave the body to sort things out as it has done over 3,000 million years. Sleep is important, as is exercise in the production of this hormone, but the quotation stresses the restful method of sleep more than strenuous exercise. This is the point that I made above, that our modern reality is STILL to exercise minimally, and thereby lead ourselves into sarcopenia and an early death. By turning it around and stressing exercise, the body will spend more time in deep sleep for repair, dreaming etc. and that aligns with what I am advocating.
The fact that the older female animals should not breed is shown in the genes of humans and that older animals in general should slow to protect the breeding stock is a necessary requirement that would be, I believe, genetic if it could be done, but failing that, evolution has handled the problem by natural selection. The term ‘death gene’ is not strictly correct, but is an apt description for a necessary condition of such importance that it can be appreciated easily. It is a condition that became important in mammals especially as the nurturing time increased as with humans, and as the Rule of Life dictates, we can’t go back for fear of reality problems.
Have I convinced you that this is a complete turnaround of evolution and will lead to a longer life and that the older people can be superior? I hope so, because there is no future in the alternative for older people! I have said previously that I believe that the mind/brain increases in creativity with age, if treated properly, and for that, ‘proper’ nutrition and exercise (for body and brain) are paramount. For hundreds of millions of years, we have been constrained by a system that demands that older members slow down to protect the young breeders and now we can change our reality and show that the older people are better than the younger. Age discrimination should be reversed! Youth unemployment is high, and older workers need re-training, but active older workers are probably the best because they have extensive experience and shouldn’t be retired!
How did we lose our way and let evolution manipulate us? Because it was necessary for the success of evolution! Now that we have a mind/brain that is a huge ‘step up’ from Survival of the Fittest (iteration), we can use Survival of the Best (mind/brain). Our reality requires measurement and evolution stopped measurement and we ‘lost our way’, so we have to take ‘control’ and use our mind/brain to do it. Existence, reality and measurement are discussed in earlier chapters and are kept to a minimum here.
So, how do we extend our lives? The first step is to regain reality by measurement. People gradually slow down because they don’t measure, and the first step is to set-up an easy way to measure. A simple way is that the mind uses concepts (see the Mathematics of the Mind in earlier chapters) and gives answers in daily life that we call ‘proverbs’ that are solutions in a general sense, so I’m going to use proverbs to make it easier. To measure, we have to ‘draw a line in the sand’ and not cross it because ‘something that we do every day, we can do forever’. Problem solved! Because we have to exercise the same every day then we can do it forever! In other words, every day we measure and keep up our level of fitness and continue doing this for as long as possible. If we decide to decrease it, we again measure and that equates to the length of our remaining life The second step is what type of exercise, and for a description of exercise as well as everything else, I suggest the Dinky Di Lifestyle Planner Diet (chapter 43).
A second way, is to think that to regain reality, we must measure our exercise because reality only occurs when we measure. Measurement produces reality because everything that you see/measure becomes real to you and that that you don’t see/sense is not part of your reality. So set an amount of exercise to do each day and do it every day. If it becomes too much to do, admit it and reduce the amount of exercise and accept that you will age, or have aged, with that decision.
This brings you to the reality of the Palaeolithic because we are assuming that the food that you consume is varied and nutritious as eaten by the hunter/gathers. However, the second Law of Life cites a relationship between state of mind, nutrition and exercise, and so nutrition has to be brought into the discussion to change our reality from the Palaeolithic to the present and that is shown in chapter 43.
In conclusion, I can imagine the reader saying ‘surely measurement is not that important’, and I would retort that technology is only possible with measurement, and furthermore, I believe that ‘we evolved reality out of the possibility of existence’ and probability space contains space-time and a fifth dimension of measurement/entanglement, and that is the relationship between reality and measurement and they don’t get more related and fundamental than that!